Select Sethi Lab Publications
Preprints
Likasitwatanakul P*, Li Z*, Doan P*, Spisak S, Raghawan AK, Liu Q, Liow P, Lee S, Chen D, Bala P, Sahgal P, Aitymbayev D, Thalappillil JS, Papanastasiou M, Hawkins W, Carr SA, Park H, Cleary JM, Qi J†, Sethi NS†. Chemical perturbations impacting histone acetylation govern colorectal cancer differentiation. bioRxiv
2024
Spisak S*, Chen D*, Likasitwatanakul P*, Doan P*, Li Z, Bala P, Vizkeleti L, Tisza V, De Silva P, Giannakis M, Wolpin B, Qi J, Sethi NS†. Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system. Nature Communications. 2024; 15(2230). PMID: 38472198
Singh H†, Sahgal P, Kapner K, Corsello SM, Gupta HV, Gujrathi R, Li YY, Cherniack AD, El Alam RH, Kerfoot J, Andrews E, Lee A, Nambiar C, Hannigan AM, Remland J, Brais LK, Leahy ME, Rubinson DA, Schlechter BL, Meyerson M, Kuang Y, Paweletz CP, Lee JK, Quintanilha JCF, Aguiree AJ, Perez KJ, Huffman BM, Rossi H, Abrams TA, Kabraji S, Trusolino L, Bertotti A, Sicinska E, Parikh AR, Wolpin BM, Schrock AB, Giannakis M, Ng K, Meyerhardt JA, Hornick JL†, Sethi NS†, Cleary JM†. RAS/RAF co-mutation and ERBB2 copy number modulates HER2 heterogeneity and responsiveness to HER2-directed therapy in colorectal cancer. Clinical Cancer Research. 2024; 30(8): 1669 PMID: 38345769
Zhang F, Shu V, Peng K, Wang Y, Li T, Bala P**, Aitymbayev D**, Sahgal P**, Schaefer A, Der CJ, Ryeom S, Yoon S, Sethi N, Bass AJ, Zhang H. Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signaling in diffuse gastric cancer. Gut. 2024 PMID: 38621923
Prosz A*, Sahgal P*, Huffman BM, Sztupinszki Z, Morris CX, Borcsok J, Diossy M, Tisza V, Spisak S, Rusz O, Csabai I, Singh H, Lazaro J-B, Cecchini M, Cleary JM, Szallasi Z†, Sethi NS†. Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting. Npj precision oncology. 2024; 8(1): 87. PMID:38589664
2023
Bala P*, Rennhack J*, Aitymbayev D, Morris C, Moyer S, Duronio GN, Doan P, Li Z, Liang X, Hornick J, Yurgelun M, Hahn WC, Sethi NS†. Aberrant cell state plasticity mediated by development reprogramming precedes colorectal cancer initiation. Science Advances. 2023; 9(13):1-17 (video about this work and press release)
Sahgal P†, Pail DT, Sztupinszki ZM, Tisza V, Spisak S, Huffman BM, Prosz A, Singh H, Lazaro J-B, Szallasi Z, Cleary JM, Sethi NS†. Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors. iScience. 2023; 26(11): 108169. PMID: 37965133
Chatia WK, Walch H, Hechtman JF, Moyer SM, Sgambati V, Faleck DM, Srivastava A, Tang L, Benhamida J, Ismailgeci D, Campos C, Wu F, Chang Q, Vakiani E, de Stanchina E, Weiser MR, Widmar M, Yantiss RK, Shah MA, Bass AJ, Stadler ZK, Mellinghoff IK, Sethi NS, Schultz N, Ganesh K, Kelsen D, Yaeger R†. Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers. Nature Communications. 2023; 14(1):110
Peng K, Zhang F, Wang Y, Sahgal P, Li T, Zhou J, Liang X**, Zhang Y, Sethi NS, Liu T, Zhang H, Bass AJ†. Development of combination strategies for focal adhesion kinase inhibition in diffuse gastric cancer. Clinical Cancer Research. 2023; 29(1):197-208. PMID: 36278961
2022
Liang X, Duronio GN, Yang Y, Bala P, Hebbar P, Spisak S, Singh H, Zhang Y, Xie Y, Cejas P, Long HW, Bass AJ, Sethi NS†. An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer. Gastroenterology 2022; 162(1): 209-2022. PMID: 34571027
Tanton H, Sewastianik T, Seo HS, Remillard D, Pierre RS, Bala P, Aitymbayev D, Dennis P, Adler K, Geffken E, Yeoh Z, Vangos N, Garbicz F, Scott D, Sethi NS, Bradner J, Dhe-Paganon S, Carrasco RD†. A novel B-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer. Science Advances. 2022. PMID 35486727
Duronio GN, Liang X, Hebbar P, Islam M, Spisak S, Sethi NS†. Truncating SOX9 alterations are heterozygous null alleles in genome stable colorectal cancer. Gastro Hep Advances. 2022; 1(5): 709-713.
Huffman BM, Ellis H, Jordan AC, Freed-Pastor WA, Perez K, Rubinson DA, Sethi NS, Singh H, Surana R, Wolpin BM, Aguirre AJ, Cleary JM†. Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma. Cancers. 2022; 14(24):6223. PMID: 36551707
2021
Saghal P, Huffman BM, Patil DT, Chatila WK, Yaeger R, Cleary JM, Sethi NS†. Early TP53 alterations shape gastric and esophageal cancer development. Cancers 2021; 13 (23): 5915 https://doi.org/10.3390/cancers13235915
Kim M, Ly S-H, Xie Y, Duronio G, Ford-Roshon D, Hwang JH, Sulahian R, Rennhack JP, So J, Gjoerup O, Talamas JA, Grandlaudon M, Long HW, Doench JG, Sethi NS, Giannakis M, Hahn WC†. YAP1 and PRDM14 converge to promote cell survival and tumorigenesis. Developmental Cell. 2021. PMID: 34990589
Cleary JM, Wolpin BM, Dougan SK, Raghavan S, Singh H, Huffman B, Sethi NS, Nowak JA, Shapiro GI, Aguirre AJ, D’Andrea AD†. Opportunities for utilization of DNA repair inhibitors in homologous recombination repair-deficient and proficient pancreatic adenocarcinoma. Clinical Cancer Research. 2021. 27(24):6622-6637. PMID: 34285063
2020
Sethi NS†, Kikuchi O, Duronio GN, Stachler MD, McFarland JM, Ferrer-Luna R, Zhang Y, Bao C, Bronson R, Patil D, Sanchez-Vega F, Liu J-B, Sicinska E, Lazaro J-B, Ligon KL, Beroukhim R, Bass AJ†. Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model. Nature Genetics 2020;52(2):219-30. PMID: 32025000
2019
Sethi N*†, Kikuchi O*, McFarland J, Zhang Y, Chung M, Kafker N, Islam M, Lampson B, Chakraborty A, Kaelin WG, Bass AJ†. Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma. JCI Insight 2019;4(15): e128439. PMID: 31391338
2018
Liu Y*; Sethi NS*; Hinoue T*; Schneider BG*; Cherniack AD; Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatlia W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, McCall AJ, Mishra L, Ojesina AI, Bullman S, Sekhar Pedamallu C, Lazar AJ, Sakai R, Cancer Genome Atlas Research Network; Thorsson, V†; Bass, AJ†; Laird, PW†. Comparative molecular analysis of gastrointestinal adenocarcinomas. Cancer Cell 2018;33(4):721-35. PMID: 29622466
2017
Sethi N†, Manesh RS, Sperling A, Bresler S, Connell NT, Tierney L. Factoring in the missing link. American Journal of Hematology 2017;92(1):110-13. PMID: 27486087
2016
Hayakawa Y; Sethi N; Sepulveda AR, Bass AJ, Wang TC. Oesophageal adenocarcinoma and gastric cancer: should we mind the gap? Nature Reviews Cancer 2016;16(5):305-18. PMID: 27112208.
Marmarelis ME, Davis MR. Sethi NS, Krajewksi KM, McKay RR, Choueiri TK, Ott PA. Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma. Journal for Immunotherapy of Cancer 2016;4:26. PMID: 27099755;
2005 - 2015
Sethi N, Kang Y. Notch signaling: mediator and therapeutic target of bone metastasis. Bonekey Reports 2012;1:3. PMID: 23951415 of
Sethi N, Dai X, Winter CG, Kang Y. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 2011; 19(2):192-205. PMID: 21295524 (Cover Article)
Sethi N, Kang Y. Dysregulation of developmental pathways in bone metastasis. Bone 2011; 48(1):16-22. PMID: 20630490.
Sethi N, Kang Y. Notch signaling in cancer progression and bone metastasis. British Journal of Cancer 2011;105(12):1805-10. PMID: 22075946
Sethi N, Kang Y. Unraveling the complexity of metastasis – molecular understanding and targeted therapies. Nature Reviews Cancer 2011;11(10):735-48. PMID: 21941285.
Sethi N, Yan Y, Quek D, Schupbach T, Kang Y. Rabconnectin-3 is a functional regulator of mammalian Notch signaling. Journal of Biological Chemistry 2010; 285(45):34757-64. PMID: 20810660
Gandhi G, Londoño D, Whetsine CR, Sethi N, Kim KS, Zückert WR, Cadavid D. Interaction of variable bacterial outer membrane lipoproteins with brain endothelium. PLOS One 2010; 5(10):e13257. PMID: 21063459
Despande G, Sethi N, Schedl P. toutvelu, a regulator of heparan sulphate proteoglycan biosynthesis, controls guidance cues for germ cell migration. Genetics 2007; 176(2): 905-12. PMID: 17409068
Sethi N, Sondey M, Bai Y, Kim KS, Cadavid D. Interaction of a neurotropic strain of Borrelia turicatae with the cerebral microcirculation system. Infection and Immunity 2006; 74(11):6408-18. PMID: 16940140; PMCID: PMC1695479.
Wolansky LJ, Haghighi MH, Sevdalis E, Cook SD, Sethi N, Liu J, Joseph G, Tulloch K, Cadavid D. Safety of serial monthly administration of triple-dose gadopentetate dimeglumine in multiple sclerosis patients: preliminary results of the BECOME trial. Journal of Neuroimaging 2005;15(3):289-90. PMID: 15951416.
* denotes equal contribution
† denotes corresponding author(s)
Likasitwatanakul P*, Li Z*, Doan P*, Spisak S, Raghawan AK, Liu Q, Liow P, Lee S, Chen D, Bala P, Sahgal P, Aitymbayev D, Thalappillil JS, Papanastasiou M, Hawkins W, Carr SA, Park H, Cleary JM, Qi J†, Sethi NS†. Chemical perturbations impacting histone acetylation govern colorectal cancer differentiation. bioRxiv
2024
Spisak S*, Chen D*, Likasitwatanakul P*, Doan P*, Li Z, Bala P, Vizkeleti L, Tisza V, De Silva P, Giannakis M, Wolpin B, Qi J, Sethi NS†. Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system. Nature Communications. 2024; 15(2230). PMID: 38472198
Singh H†, Sahgal P, Kapner K, Corsello SM, Gupta HV, Gujrathi R, Li YY, Cherniack AD, El Alam RH, Kerfoot J, Andrews E, Lee A, Nambiar C, Hannigan AM, Remland J, Brais LK, Leahy ME, Rubinson DA, Schlechter BL, Meyerson M, Kuang Y, Paweletz CP, Lee JK, Quintanilha JCF, Aguiree AJ, Perez KJ, Huffman BM, Rossi H, Abrams TA, Kabraji S, Trusolino L, Bertotti A, Sicinska E, Parikh AR, Wolpin BM, Schrock AB, Giannakis M, Ng K, Meyerhardt JA, Hornick JL†, Sethi NS†, Cleary JM†. RAS/RAF co-mutation and ERBB2 copy number modulates HER2 heterogeneity and responsiveness to HER2-directed therapy in colorectal cancer. Clinical Cancer Research. 2024; 30(8): 1669 PMID: 38345769
Zhang F, Shu V, Peng K, Wang Y, Li T, Bala P**, Aitymbayev D**, Sahgal P**, Schaefer A, Der CJ, Ryeom S, Yoon S, Sethi N, Bass AJ, Zhang H. Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signaling in diffuse gastric cancer. Gut. 2024 PMID: 38621923
Prosz A*, Sahgal P*, Huffman BM, Sztupinszki Z, Morris CX, Borcsok J, Diossy M, Tisza V, Spisak S, Rusz O, Csabai I, Singh H, Lazaro J-B, Cecchini M, Cleary JM, Szallasi Z†, Sethi NS†. Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting. Npj precision oncology. 2024; 8(1): 87. PMID:38589664
2023
Bala P*, Rennhack J*, Aitymbayev D, Morris C, Moyer S, Duronio GN, Doan P, Li Z, Liang X, Hornick J, Yurgelun M, Hahn WC, Sethi NS†. Aberrant cell state plasticity mediated by development reprogramming precedes colorectal cancer initiation. Science Advances. 2023; 9(13):1-17 (video about this work and press release)
- Commentary: Billingsley et al. Colorectal Cancer is Borrowing Blueprints from Intestinal Ontogenesis. Cancers 2023. 15(20), 4928.
Sahgal P†, Pail DT, Sztupinszki ZM, Tisza V, Spisak S, Huffman BM, Prosz A, Singh H, Lazaro J-B, Szallasi Z, Cleary JM, Sethi NS†. Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors. iScience. 2023; 26(11): 108169. PMID: 37965133
Chatia WK, Walch H, Hechtman JF, Moyer SM, Sgambati V, Faleck DM, Srivastava A, Tang L, Benhamida J, Ismailgeci D, Campos C, Wu F, Chang Q, Vakiani E, de Stanchina E, Weiser MR, Widmar M, Yantiss RK, Shah MA, Bass AJ, Stadler ZK, Mellinghoff IK, Sethi NS, Schultz N, Ganesh K, Kelsen D, Yaeger R†. Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers. Nature Communications. 2023; 14(1):110
Peng K, Zhang F, Wang Y, Sahgal P, Li T, Zhou J, Liang X**, Zhang Y, Sethi NS, Liu T, Zhang H, Bass AJ†. Development of combination strategies for focal adhesion kinase inhibition in diffuse gastric cancer. Clinical Cancer Research. 2023; 29(1):197-208. PMID: 36278961
2022
Liang X, Duronio GN, Yang Y, Bala P, Hebbar P, Spisak S, Singh H, Zhang Y, Xie Y, Cejas P, Long HW, Bass AJ, Sethi NS†. An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer. Gastroenterology 2022; 162(1): 209-2022. PMID: 34571027
Tanton H, Sewastianik T, Seo HS, Remillard D, Pierre RS, Bala P, Aitymbayev D, Dennis P, Adler K, Geffken E, Yeoh Z, Vangos N, Garbicz F, Scott D, Sethi NS, Bradner J, Dhe-Paganon S, Carrasco RD†. A novel B-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer. Science Advances. 2022. PMID 35486727
Duronio GN, Liang X, Hebbar P, Islam M, Spisak S, Sethi NS†. Truncating SOX9 alterations are heterozygous null alleles in genome stable colorectal cancer. Gastro Hep Advances. 2022; 1(5): 709-713.
Huffman BM, Ellis H, Jordan AC, Freed-Pastor WA, Perez K, Rubinson DA, Sethi NS, Singh H, Surana R, Wolpin BM, Aguirre AJ, Cleary JM†. Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma. Cancers. 2022; 14(24):6223. PMID: 36551707
2021
Saghal P, Huffman BM, Patil DT, Chatila WK, Yaeger R, Cleary JM, Sethi NS†. Early TP53 alterations shape gastric and esophageal cancer development. Cancers 2021; 13 (23): 5915 https://doi.org/10.3390/cancers13235915
Kim M, Ly S-H, Xie Y, Duronio G, Ford-Roshon D, Hwang JH, Sulahian R, Rennhack JP, So J, Gjoerup O, Talamas JA, Grandlaudon M, Long HW, Doench JG, Sethi NS, Giannakis M, Hahn WC†. YAP1 and PRDM14 converge to promote cell survival and tumorigenesis. Developmental Cell. 2021. PMID: 34990589
Cleary JM, Wolpin BM, Dougan SK, Raghavan S, Singh H, Huffman B, Sethi NS, Nowak JA, Shapiro GI, Aguirre AJ, D’Andrea AD†. Opportunities for utilization of DNA repair inhibitors in homologous recombination repair-deficient and proficient pancreatic adenocarcinoma. Clinical Cancer Research. 2021. 27(24):6622-6637. PMID: 34285063
2020
Sethi NS†, Kikuchi O, Duronio GN, Stachler MD, McFarland JM, Ferrer-Luna R, Zhang Y, Bao C, Bronson R, Patil D, Sanchez-Vega F, Liu J-B, Sicinska E, Lazaro J-B, Ligon KL, Beroukhim R, Bass AJ†. Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model. Nature Genetics 2020;52(2):219-30. PMID: 32025000
- Comment in: Ray K. New markers and models of premalignancy and the early development of gastric cancer. Nature Reviews Gastroenterology & Hepatology 2020. Apr;17(4):193.
2019
Sethi N*†, Kikuchi O*, McFarland J, Zhang Y, Chung M, Kafker N, Islam M, Lampson B, Chakraborty A, Kaelin WG, Bass AJ†. Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma. JCI Insight 2019;4(15): e128439. PMID: 31391338
2018
Liu Y*; Sethi NS*; Hinoue T*; Schneider BG*; Cherniack AD; Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatlia W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, McCall AJ, Mishra L, Ojesina AI, Bullman S, Sekhar Pedamallu C, Lazar AJ, Sakai R, Cancer Genome Atlas Research Network; Thorsson, V†; Bass, AJ†; Laird, PW†. Comparative molecular analysis of gastrointestinal adenocarcinomas. Cancer Cell 2018;33(4):721-35. PMID: 29622466
2017
Sethi N†, Manesh RS, Sperling A, Bresler S, Connell NT, Tierney L. Factoring in the missing link. American Journal of Hematology 2017;92(1):110-13. PMID: 27486087
2016
Hayakawa Y; Sethi N; Sepulveda AR, Bass AJ, Wang TC. Oesophageal adenocarcinoma and gastric cancer: should we mind the gap? Nature Reviews Cancer 2016;16(5):305-18. PMID: 27112208.
Marmarelis ME, Davis MR. Sethi NS, Krajewksi KM, McKay RR, Choueiri TK, Ott PA. Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma. Journal for Immunotherapy of Cancer 2016;4:26. PMID: 27099755;
2005 - 2015
Sethi N, Kang Y. Notch signaling: mediator and therapeutic target of bone metastasis. Bonekey Reports 2012;1:3. PMID: 23951415 of
Sethi N, Dai X, Winter CG, Kang Y. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 2011; 19(2):192-205. PMID: 21295524 (Cover Article)
- Comment in: Tao, J; Erez, A; Lee, B. One NOTCH Further: Jagged1 in Bone Metastasis. Cancer Cell. 2011; 19(2):159-61. PMID: 21316596
- Highlighted by Cancer Cell’s 10th year anniversary celebration as one of the top 5 studies published by the journal in 2011
Sethi N, Kang Y. Dysregulation of developmental pathways in bone metastasis. Bone 2011; 48(1):16-22. PMID: 20630490.
Sethi N, Kang Y. Notch signaling in cancer progression and bone metastasis. British Journal of Cancer 2011;105(12):1805-10. PMID: 22075946
Sethi N, Kang Y. Unraveling the complexity of metastasis – molecular understanding and targeted therapies. Nature Reviews Cancer 2011;11(10):735-48. PMID: 21941285.
Sethi N, Yan Y, Quek D, Schupbach T, Kang Y. Rabconnectin-3 is a functional regulator of mammalian Notch signaling. Journal of Biological Chemistry 2010; 285(45):34757-64. PMID: 20810660
Gandhi G, Londoño D, Whetsine CR, Sethi N, Kim KS, Zückert WR, Cadavid D. Interaction of variable bacterial outer membrane lipoproteins with brain endothelium. PLOS One 2010; 5(10):e13257. PMID: 21063459
Despande G, Sethi N, Schedl P. toutvelu, a regulator of heparan sulphate proteoglycan biosynthesis, controls guidance cues for germ cell migration. Genetics 2007; 176(2): 905-12. PMID: 17409068
Sethi N, Sondey M, Bai Y, Kim KS, Cadavid D. Interaction of a neurotropic strain of Borrelia turicatae with the cerebral microcirculation system. Infection and Immunity 2006; 74(11):6408-18. PMID: 16940140; PMCID: PMC1695479.
Wolansky LJ, Haghighi MH, Sevdalis E, Cook SD, Sethi N, Liu J, Joseph G, Tulloch K, Cadavid D. Safety of serial monthly administration of triple-dose gadopentetate dimeglumine in multiple sclerosis patients: preliminary results of the BECOME trial. Journal of Neuroimaging 2005;15(3):289-90. PMID: 15951416.
* denotes equal contribution
† denotes corresponding author(s)
Complete publication list can be found here.
Sethi Lab - Gastrointestinal Malignancies
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