Sethi Lab - Gastrointestinal Cancer Research
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DISEASE MODELS


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​We recently built a new mouse model that combines early genetic alterations with disease-relevant dietary carcinogens to study gastric premalignancy.  Using this model, we learned that early TP53 alterations ultimately lead to premalignant lesions that have a selective pressure to alter a cell cycle regulator.  Although this second alteration enabled disease progression, it also yielded a therapeutic vulnerability.


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​After realizing that hypoxia transcriptional programs may be heightened in p53 mutant gastric and esophageal adenocarcinomas, we designed an in vivo system to measure hypoxia activity in real-time during xenograft tumor growth. Using this system, we were able to identify a new dependency in these deadly cancers.
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​We have designed a genetically engineered mouse model to characterize the functional and clinical significance of SOX9 alterations in colorectal cancer. Phenotypic evaluation, histopathological analyses, and molecular studies (e.g. single-cell RNA-sequencing) of this model will enable a thorough understanding of the genome stable subtype of colorectal cancer. 
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©2020 Sethi Lab at Dana-Farber Cancer Institute
  • HOME
  • RESEARCH
    • Cancer Genomics
    • Disease Models
    • Therapeutic Vulnerabilities
  • PEOPLE
    • Principal Investigator
    • Lab Members
    • Alumni
    • Collaborators
    • Photo Gallery
  • PUBLICATIONS
  • SUPPORT
  • CONTACT