A comparative molecular analysis of esophageal, gastric and colorectal adenocarcinomas revealed several key findings:
We identified a previously unrecognized subtype of colorectal cancer that lacks hypermutation and significant aneuploidy known as genome stable. A striking feature of this subtype is recurrent mutations in the transcription factor SOX9. The lab is focused on defining the clinical and functional significance of SOX9 mutations using genetically engineered mouse models, organoid systems, and single-cell transcriptomics.
Duronio et al., Gastro Hep Advances, 2022